Ophthalmology- February 2016

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Welcome to the January 2016 Update. This will be produced every month and lists the most recent literature in the field. Full text links are provided where available please login to Athens to access the Full text. If you do not have an NHS Open Athens account please register at http://openathens.nice.org.uk/

Good Hope, Heartlands and Solihull Libraries supply Full texts from other libraries in the region including the British Library.

ASK a Librarian at Good Hope: x 47833; Heartlands: x 42583; Solihull:  x 45196

You may also access journals via www.evidence.nhs.uk using your Athens account.

New and Updated Cochrane Reviews

Aflibercept for neovascular age-related macular degeneration

Salman Sarwar , Elizabeth Clearfield , Mohamed Kamel Soliman , Mohammad Ali Sadiq , Andrew J Baldwin  Mostafa Hanout , Aniruddha Agarwal , Yasir J Sepah , Diana V Do and Quan Dong Nguyen

Online Publication Date: February 2016


Interventions to increase attendance for diabetic retinopathy screening


John G Lawrenson, Ella Graham-Rowe, Fabiana Lorencatto, Justin Presseau, Jennifer Burr, Noah Ivers, Ana Quartilho, Catey Bunce, Jillian J Francis, Jeremy M Grimshaw, Tunde Peto, Stephen Rice, Luke Vale


First published: 27 January 2016


Anti-vascular endothelial growth factor for control of wound healing in glaucoma surgery

Jin-Wei Cheng Shi-Wei Cheng Rui-Li Wei Guo-Cai Lu

Published Online: 15 JAN 2016


Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis

Ayokunle T Abegunde Richard M Ahuja Nkem J Okafor


Published Online: 15 JAN 2016



Interventions for central serous chorioretinopathy: a network meta‐analysis

Mahsa Salehi, Adam S Wenick, Hua Andrew Law, Jennifer R Evans, Peter Gehlbach

Online Publication Date: December 2015


Medical interventions for treating primary angle‐closure glaucoma




Xuan Hui, Manuele Michelessi

Online Publication Date: December 2015


Device‐modified trabeculectomy for glaucoma


Xue Wang, Rabeea Khan, Anne Coleman

Online Publication Date: December 2015


Optic nerve head and fibre layer imaging for diagnosing glaucoma


Manuele Michelessi, Ersilia Lucenteforte, Francesco Oddone, Miriam Brazzelli, Mariacristina Parravano, Sara Franchi, Sueko M Ng, Gianni Virgili

Online Publication Date: November 2015


Blue‐light filtering intraocular lenses (IOLs) for protecting macular health


Laura E Downie, Ljoudmila Busija, Peter R Keller

Online Publication Date: November 2015


Fornix‐based versus limbal‐based conjunctival trabeculectomy flaps for glaucoma


Christiane Al‐Haddad, Marwan Abdulaal, Ahmad Al‐Moujahed, Ann‐Margret Ervin

Online Publication Date: November 2015


Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy


Zi Wei Liu, Liam Masterson, Brian Fish, Piyush Jani, Krishna Chatterjee

Online Publication Date: November 2015


Topical treatments for blepharokeratoconjunctivitis in children


Michael O'Gallagher, Catey Bunce, Melanie Hingorani, Frank Larkin, Stephen Tuft, Annegret Dahlmann‐Noor

Online Publication Date: November 2015


Interventions for trachoma trichiasis


Matthew Burton, Esmael Habtamu, Derek Ho, Emily W Gower

Online Publication Date: November 2015


Mitomycin C versus 5‐Fluorouracil for wound healing in glaucoma surgery


Emily Cabourne, Jonathan CK Clarke, Patricio G Schlottmann, Jennifer R Evans

Online Publication Date: November 2015


Day care versus in‐patient surgery for age‐related cataract


David Lawrence, Zbys Fedorowicz, Esther J van Zuuren

Online Publication Date: November 2015


Laser therapy for retinopathy in sickle cell disease


Kay Thi Myint, Soumendra Sahoo, Aung Win Thein, Soe Moe, Han Ni

Online Publication Date: October 2015




Interventions for the management of CMV‐associated anterior segment inflammation


Arundhati Anshu, Donald Tan, Soon‐Phaik Chee, Jod S Mehta, Hla M Htoon

Online Publication Date: October 2015

Age related Macular degeneration/Odema



Brown MM, Brown GC, Lieske HB, Tran I, Turpcu A, Colman S.

Retina. 2016 Feb;36(2):285-98.



Andonegui J, Aliseda D, Serrano L, Eguzkiza A, Arruti N, Arias L, Alcaine A.

Retina. 2016 Feb;36(2):279-84.

Macular Morphology and Visual Acuity in the Second Year of the Comparison of Age-related Macular Degeneration Treatments Trials.

Sharma S, Toth CA, Daniel E, Grunwald JE, Maguire MG, Ying GS, Huang J, Martin DF, Jaffe GJ; Comparison of Age-related Macular Degeneration Treatments Trials Research Group.

Ophthalmology. 2016 Jan 9. pii: S0161-6420(15)01424-4. doi: 10.1016/j.ophtha.2015.12.002. [Epub ahead of print] (link to pdf)


Angiographic Cystoid Macular Edema and Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Shah N, Maguire MG, Martin DF, Shaffer J, Ying GS, Grunwald JE, Toth CA, Jaffe GJ, Daniel E; Comparison of Age-related Macular Degeneration Treatments Trials Research Group.

Ophthalmology. 2016 Jan 8. pii: S0161-6420(15)01421-9. doi: 10.1016/j.ophtha.2015.11.030. [Epub ahead of print] (link to pdf)

Comparison of Visual Function in Older Eyes in the Earliest Stages of Age-related Macular Degeneration to Those in Normal Macular Health.

Owsley C, Huisingh C, Clark ME, Jackson GR, McGwin G Jr.

Curr Eye Res. 2016 Feb;41(2):266-72. doi: 10.3109/02713683.2015.1011282. Epub 2015 Mar 24.

(link to pdf)

The design and implementation of a study to investigate the effectiveness of community vs hospital eye service follow-up for patients with neovascular age-related macular degeneration with quiescent disease 

J Taylor, L J Scott, C A Rogers, A Muldrew, D O'Reilly, S Wordsworth, N Mills, R Hogg, M Violato, S P Harding, T Peto, D Townsend, U Chakravarthy and B C Reeves

Eye 30: 68-78; advance online publication, October 9, 2015; doi:10.1038/eye.2015.170 (full text link)



Querques, Giuseppe MD, PhD; Kamami-Levy, Cynthia MD, MSc; Georges, Anouk MD; Pedinielli, Alexandre MD; Capuano, Vittorio MD; Blanco-Garavito, Rocio MD; Poulon, Fanny MSc; Souied, Eric H. MD, PhD

Retina: February 2016 - Volume 36 - Issue 2 - p 247–254 (full text link)



De Bats, Flore; Mathis, Thibaud; Mauget-Faÿsse, Martine; More

Retina. 36(1):46-52, January 2016


Association between Antiplatelet or Anticoagulant Drugs and Retinal or Subretinal Hemorrhage in the Comparison of Age-Related Macular Degeneration Treatments Trials Ying, Gui-shuang et al.

Ophthalmology , Volume 123 , Issue 2 , 352 – 360 (full text link)

First-Year Visual Acuity Outcomes of Providing Aflibercept According to the VIEW Study Protocol for Age-Related Macular Degeneration Talks, James S.Lobo, Aires et al.

Ophthalmology , Volume 123 , Issue 2 , 337 – 343 (full text link)

Natural History of Geographic Atrophy Progression Secondary to Age-Related Macular Degeneration (Geographic Atrophy Progression Study) Schmitz-Valckenberg, Steffen et al.

Ophthalmology , Volume 123 , Issue 2 , 361 – 368 (full text link)

Delayed Rod-Mediated Dark Adaptation Is a Functional Biomarker for Incident Early Age-Related Macular Degeneration Owsley, Cynthia et al.

Ophthalmology , Volume 123 , Issue 2 , 344 – 351 (full text link)

Correlation of 3-Dimensionally Quantified Intraretinal and Subretinal Fluid With Visual Acuity in Neovascular Age-Related Macular Degeneration

Sebastian M. Waldstein, MD1; Ana-Maria Philip, MDet al

JAMA Ophthalmol. 2016;134(2):182-190 (available to read in eye library)

The design and implementation of a study to investigate the effectiveness of community vs hospital eye service follow-up for patients with neovascular age-related macular degeneration with quiescent disease

J Taylor L J Scott C A Rogers

Eye (Lond). 2016 Jan; 30(1): 68–78.


Comparative Effectiveness of Antibiotic Prophylaxis in Cataract Surgery

Herrinton, Lisa J. et al.

Ophthalmology , Volume 123 , Issue 2 , 287 – 294 (full text link)

 Longitudinal Study of Age-Related Cataract Using Dynamic Light Scattering

Datiles, Manuel B. et al.

Ophthalmology , Volume 123 , Issue 2 , 248 – 254 (full text link)

Endophthalmitis Occurring after Cataract Surgery Jabbarvand, Mahmoud et al.

Ophthalmology , Volume 123 , Issue 2 , 295 – 301 (full text link)

Risk Factors and Incidence of Macular Edema after Cataract Surgery Chu, Colin J. et al.

Ophthalmology , Volume 123 , Issue 2 , 316 – 323 (full text link)

Comparison of Manual, Femtosecond Laser, and Precision Pulse Capsulotomy Edge Tear Strength in Paired Human Cadaver Eyes  Thompson, Vance M. et al.

Ophthalmology , Volume 123 , Issue 2 , 265 – 274 (full text link)

Central Serous


Liu, Bing; Deng, Tuo; Zhang, Junjun

Retina. 36(1):9-19, January 2016.


Acta Ophthalmol. 2016 Feb;94(1):e54-8. doi: 10.1111/aos.12795. Epub 2015 Jun 24.

Clinical application of 3D display device in ophthalmology: measurement of metamorphopsia. (abstract only)

Kim JW  Kim YT



Moschos MM, Gazouli M, Gatzioufas Z, Brouzas D, Nomikarios N, Sivaprasad S, Mitropoulos P, Chatziralli IP.

Retina. 2016 Feb;36(2):402-7.

Photodynamic therapy: current role in the treatment of chorioretinal conditions. (abstract only)

Newman DK.

Eye (Lond). 2016 Jan 8. doi: 10.1038/eye.2015.251. [Epub ahead of print]



El Ameen A, Mrejen-Uretsky S, Abraham J, Souied EH, Cohen SY.

Retin Cases Brief Rep. 2016 Jan 8. [Epub ahead of print]


Multimodal Imaging and Choroidal Volumetric Changes After Half-fluence PDT in Central Serous Chorioretinopathy.

Munk MR, Shah R, Pappas F, Baddar D, Wong B, Jampol LM, Fawzi AA.

Curr Eye Res. 2016 Jan;41(1):97-106. doi: 10.3109/02713683.2014.1002047. Epub 2015 Jan 22.


Photodynamic therapy and anti-vascular endothelial growth factor for acute central serous chorioretinopathy: a systematic review and meta-analysis.

Lu HQ, Wang EQ, Zhang T, Chen YX.

Eye (Lond). 2016 Jan;30(1):15-22. doi: 10.1038/eye.2015.208. Epub 2015 Oct 30. Review. (full text link)


Oral Rifampin treatment for longstanding chronic central serous chorioretinopathy. (abstract only)

Shulman S, Goldenberg D, Schwartz R, Habot-Wilner Z, Barak A, Ehrlich N, Loewenstein A, Goldstein M.

Graefes Arch Clin Exp Ophthalmol. 2016 Jan;254(1):15-22. doi: 10.1007/s00417-015-2989-z. Epub 2015 Mar 21.


Selective Retina Therapy in Patients With Chronic Central Serous Chorioretinopathy: A Pilot Study. (abstract only)

Kang S, Park YG, Kim JR, Seifert E, Dirk TK, Ralf B, Roh YJ.

Medicine (Baltimore). 2016 Jan;95(3):e2524




Dave T, Dave VP, Shah G, Pappuru RR.

Retin Cases Brief Rep. 2016 Winter;10(1):11-4.


Corneal Nerve Regeneration After Collagen Cross-Linking Treatment of KeratoconusA 5-Year Longitudinal Study

Marlen Parissi, MSc1,2; Stefan Randjelovic, MSc2; Enea Poletti, PhD3; Pedro Guimarães, PhD3; Alfredo Ruggeri, PhD3; Sofia Fragkiskou, MD4; Thu Ba Wihlmark, MD4; Tor Paaske Utheim, MD, PhD1,2,5; Neil Lagali, PhD4

JAMA Ophthalmol. 2016;134(1):70-78. doi:10.1001/jamaophthalmol.2015.4518. (full text available to read in eye library)

Effect of Photorefractive Keratectomy on Nystagmus and Visual Functions in Myopic Patients With Infantile Nystagmus Syndrome Abbas Bagheri, Hamed Abbasi, Mehdi Tavakoli, Alireza Baradaran-Rafii, Abdolreza Shaibanizadeh, Bahareh Kheiri, Shahin Yazdani

Am J Ophthalmol 2016;162: 167–172 (pdf link)

Visual Acuity Outcomes of the Boston Keratoprosthesis Type 1: Multicenter Study Results

Christopher J. Rudnisky, Michael W. Belin, Rong Guo, Joseph B. Ciolino, Boston Type 1 Keratoprosthesis Study Group

Am J Ophthalmol  Volume 162, February 2016, Pages 89–98.e1 (pdf link)

Reliability of Pentacam HR Thickness Maps of the Entire Cornea in Normal, Post–Laser In Situ Keratomileusis, and Keratoconus Eyes  Zhe Xu, Mei Peng, Jun Jiang, Chun Yang, Weigen Zhu, Fan Lu, Meixiao Shen

Am J Ophthalmol  Volume 162, February 2016, Pages 74–82.e1 (pdf link)

Outcomes of Repeat Keratoplasty for Failed Therapeutic Keratoplasty

Shreyas Ramamurthy Jagadesh C. Reddy et al

Am J Ophthalmol  Volume 162, February 2016, Pages 83-88.e2 (full text link)


Reliability of Pentacam HR Thickness Maps of the Entire Cornea in Normal, Post–Laser In Situ Keratomileusis, and Keratoconus Eyes

Zhe Xu  Mei Peng  Jun Jiang

Am J Ophthalmol  Volume 162, February 2016, Pages 74-82.e1 (full text link)

An Analysis of Factors Influencing Quality of Vision After Big-Bubble Deep Anterior Lamellar Keratoplasty in Keratoconus

Sepehr Feiz et al

Am J Ophthalmol  Volume 162, February 2016, Pages 66-73.e2 (full text link)



Diabetic Macular Odema

Association of Baseline Visual Acuity and Retinal Thickness With 1-Year Efficacy of Aflibercept, Bevacizumab, and Ranibizumab for Diabetic Macular Edema


John A. Wells, MD; Adam R. Glassman et al

JAMA Ophthalmol2016;134(2):127-134 (full text available to read in eye library)


Risk Factors and Incidence of Macular Edema after Cataract Surgery: A Database Study of 81984 Eyes.

Chu CJ1Johnston RL2Buscombe C3Sallam AB4Mohamed Q3Yang YC5United Kingdom Pseudophakic Macular Edema Study Group.


Ophthalmology 2016 Feb;123(2):316-23. doi: 10.1016/j.ophtha.2015.10.001. Epub 2015 Dec 8. (full text link)



A randomized clinical trial comparing fixed vs pro-re-nata dosing of Ozurdex in refractory diabetic macularoedema (OZDRY study).

Ramu J1Yang Y2Menon G3Bailey C4Narendran N2Bunce C1Quartilho A1Prevost AT5Hykin P1Sivaprasad S1.

Eye (Lond). 2015 Dec;29(12):1603-12. doi: 10.1038/eye.2015.214. Epub 2015 Oct 23.


Analysis of costs associated with the management and morbidity of diabetic macular oedema and macular oedema secondary to retinal vein occlusion.

Abraldes MJ, Pareja A, Roura M; en representación del grupo del estudio OBSERVAR.

Arch Soc Esp Oftalmol. 2016 Jan 19. pii: S0365-6691(15)00361-5. doi: 10.1016/j.oftal.2015.11.019. [Epub ahead of print] English, Spanish.

PMID: 26810908 [PubMed - as supplied by publisher]


Miháltz, Kata; Kovács, Illés; Weingessel, Birgit; More

Retina. 36(1):28-36, January 2016.



Alshahrani, Saeed T.; Dolz-Marco, Rosa; Gallego-Pinazo, Roberto; More

Retina. 36(1):131-136, January 2016.


Systemic Safety of Prolonged Monthly Anti–Vascular Endothelial Growth Factor Therapy for Diabetic Macular EdemaA Systematic Review and Meta-analysis

Robert L. Avery, MD1; Gabriel M. Gordon, PhD1

JAMA Ophthalmol. 2016;134(1):21-29. doi:10.1001/jamaophthalmol.2015.4070. (full text available to read in eye library)

Algorithm for the Measure of Vitreous Hyperreflective Foci in Optical Coherence Tomographic Scans of Patients With Diabetic Macular Edema

Edward Korot, MD1,2; Grant Comer, MD2; Timothy Steffens, MA2; David A. Antonetti, PhD2

JAMA Ophthalmol. 2016;134(1):15-20. doi:10.1001/jamaophthalmol.2015.3949. (full text available to read in eye library)

Intravitreal Aflibercept for Macular Edema Following Branch Retinal Vein Occlusion Clark, W. Lloyd et al.

Ophthalmology , Volume 123 , Issue 2 , 330 – 336 (full text link)

Effect of Ranibizumab on the Decision to Drive and Vision Function Relevant to Driving in Patients With Diabetic Macular Edema: Report From RESTORE, RIDE, and RISE Trials

Neil M. Bressler, MD1  Rohit Varma, MD et al

JAMA Ophthalmol. 2016;134(2):160-166 (full text available to read in eye library)

Diabetic Screening


Storey, Philip P.; Murchison, Ann P.; Pizzi, Laura T.; More

Retina. 36(1):20-27, January 2016.


Comparison of the Abilities of SD-OCT and SS-OCT in Evaluating the Thickness of the Macular Inner Retinal Layer for Glaucoma Diagnosis. (abstract only)

Lee KM, Lee EJ, Kim TW, Kim H.

PLoS One. 2016 Jan 26;11(1):e0147964. doi: 10.1371/journal.pone.0147964. eCollection 2016.

PMID: 26812064 [PubMed - in process] (full text link)


Effect of Visual Impairment on Teleretinal Imaging for Diabetic Retinopathy Screening.

Rico-Sergado L, Pérez-Canales JL, Pérez-Santonja JJ.

Ophthalmic Surg Lasers Imaging Retina. 2016 Jan 1;47(1):42-8.


Diabetic retinopathy screening: experiences from northern Tanzania.

Cleland CR, Burton MJ, Hall C, Hall A, Courtright P, Makupa WU, Philippin H.

Lancet Diabetes Endocrinol. 2016 Jan;4(1):10-2. doi: 10.1016/S2213-8587(15)00422-2. Epub 2015 Dec 3. No abstract available.

PMID: 26656290 [PubMed - in process]


Immediate Intraocular Pressure Changes Following Intravitreal Dexamethasone Implant.

Alagöz N, Alagöz C, Yılmaz I, Yıldırım Y, Baz Ö, Altan Ç, Yazıcı AT, Taşkapılı M.

J Ocul Pharmacol Ther. 2016 Jan-Feb;32(1):44-9. doi: 10.1089/jop.2015.0087. Epub 2015 Nov 5.

PMID: 26540554 [PubMed - in process]

Systematic screening for diabetic retinopathy (DR) in Hong Kong: prevalence of DR and visual impairment among diabetic population.

Lian JX, Gangwani RA, McGhee SM, Chan CK, Lam CL; Primary Health Care Group,, Wong DS; Primary Health Care Group.

Br J Ophthalmol. 2016 Feb;100(2):151-5. doi: 10.1136/bjophthalmol-2015-307382. Epub 2015 Aug 13.

(full text link)

Report on the creation of a diabetes register and retinopathy screening outcomes in the Mid-West of Ireland.

James M, Goodchild C, Bashir S, Mannix M.

Ir J Med Sci. 2016 Feb;185(1):151-9. doi: 10.1007/s11845-015-1248-y. Epub 2015 Jan 17.

PMID: 25595828 [PubMed - in process]

Smartphone-Based Dilated Fundus Photography and Near Visual Acuity Testing as Inexpensive Screening Tools to Detect Referral Warranted Diabetic Eye Disease.

Toy BC, Myung DJ, He L, Pan CK, Chang RT, Polkinhorne A, Merrell D, Foster D, Blumenkranz MS.

Retina. 2016 Jan 19. [Epub ahead of print]

PMID: 26807627 [PubMed - as supplied by publisher]

Extending the diabetic retinopathy screening interval beyond 1 year: systematic review.

Taylor-Phillips S, Mistry H, Leslie R, Todkill D, Tsertsvadze A, Connock M, Clarke A.

Br J Ophthalmol. 2016 Jan;100(1):105-14. doi: 10.1136/bjophthalmol-2014-305938. Epub 2015 Jan 13. Review.

PMID: 25586713 [PubMed - in process] (full text link)

Diabetic Retinopathy Screening and Monitoring of Early Stage Disease in Australian General Practice: Tackling Preventable Blindness within a Chronic Care Model.

Crossland L, Askew D, Ware R, Cranstoun P, Mitchell P, Bryett A, Jackson C.

J Diabetes Res. 2016;2016:8405395. doi: 10.1155/2016/8405395. Epub 2015 Dec 20.

PMID: 26798655 [PubMed - in process] (full text link)

An Innovative Australian Outreach Model of Diabetic Retinopathy Screening in Remote Communities.

Glasson NM, Crossland LJ, Larkins SL.

J Diabetes Res. 2016;2016:1267215. doi: 10.1155/2016/1267215. Epub 2015 Dec 20.

PMID: 26798648 [PubMed - in process] (full text link)

Detection of Glaucoma and Its Association With Diabetic Retinopathy in a Diabetic Retinopathy Screening Program.

Gangwani RA, McGhee SM, Lai JS, Chan CK, Wong D.

J Glaucoma. 2016 Jan;25(1):101-5. doi: 10.1097/IJG.0000000000000138.

PMID: 25264989 [PubMed - in process]

Effect of Visual Impairment on Teleretinal Imaging for Diabetic Retinopathy Screening.

Rico-Sergado L, Pérez-Canales JL, Pérez-Santonja JJ.

Ophthalmic Surg Lasers Imaging Retina. 2016 Jan 1;47(1):42-8. doi: 10.3928/23258160-20151214-06.

PMID: 26731208 [PubMed - in process]

Ketoacidosis at diagnosis in childhood-onset diabetes and the risk of retinopathy 20years later.

Salardi S, Porta M, Maltoni G, Cerutti F, Rovere S, Iafusco D, Tumini S, Cauvin V, Zucchini S, Cadario F, dʾAnnunzio G, Toni S, Salvatoni A, Zedda MA, Schiaffini R; Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED).

J Diabetes Complications. 2016 Jan-Feb;30(1):55-60. doi: 10.1016/j.jdiacomp.2015.10.009. Epub 2015 Oct 20.

PMID: 26598223 [PubMed - in process]

Evaluation of Automated Teleretinal Screening Program for Diabetic Retinopathy


O. Bennett Walton IV, MD, MBA1,2; Robert B. Garoon, MD et al

JAMA Ophthalmol2016;134(2):204-209

Diabetic Retinopathy

SYSTEMIC INTERLEUKIN 1β INHIBITION IN PROLIFERATIVE DIABETIC RETINOPATHY: A Prospective Open-Label Study Using Canakinumab (link to abstract and full text)

Stahel, Marc; Becker, Matthias; Graf, Nicole; More

Retina. 36(2):385-391, February 2016.


The Royal College of Ophthalmologists’ National Ophthalmology Database Study of Vitreoretinal SurgeryReport 6, Diabetic Vitrectomy

Timothy L. Jackson, PhD, FRCOphth1; Robert L. Johnston, FRCOphth2,3; Paul H. J. Donachie, MSc2,3; Tom H. Williamson, MD, FRCOphth4; John M. Sparrow, DPhil, FRCOphth2,5; David H. W. Steel, FRCOphth6,7

JAMA Ophthalmol. 2016;134(1):79-85. doi:10.1001/jamaophthalmol.2015.4587. (full text available to read in eye library)

Effects of Prior Intensive Insulin Therapy and Risk Factors on Patient-Reported Visual Function Outcomes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Cohort

Writing Team for the DCCT/EDIC Research Group

JAMA Ophthalmol. 2016;134(2):137-145

Future Promise of and Potential Pitfalls for Automated Detection of Diabetic Retinopathy

Sun JK, Cavallerano JD, Silva PS.

JAMA Ophthalmol. 2016 Feb 1;134(2):210-1

Spectral domain ocular coherence tomography findings pre- and post vitrectomy with fibrovascular membrane delamination for proliferative diabetic retinopathy

Dooley I, Laviers H, Papavasileiou E, Mckechnie C, Zambarakji H.

Eye (Lond). 2016 Jan;30(1):34-9. doi: 10.1038/eye.2015.178. Epub 2015 Sep 25. (full text link)


Diabetic Retinopathy: Animal Models, Therapies, and Perspectives

Cai X, McGinnis JF.

J Diabetes Res. 2016;2016:3789217. doi: 10.1155/2016/3789217. Epub 2016 Jan 6. Review. (full text link)


Ranibizumab for High-Risk Proliferative Diabetic Retinopathy: An Exploratory Randomized Controlled Trial

Figueira J, Silva R, Henriques J, Caldeira Rosa P, Laíns I, Melo P, Gonçalves Nunes S, Cunha-Vaz J.

Ophthalmologica. 2016;235(1):34-41. doi: 10.1159/000442026. Epub 2015 Dec 3.


A Comparison of Immediate and Delayed Vitrectomy for the Management of Vitreous Hemorrhage due to Proliferative Diabetic Retinopathy

Fassbender JM, Ozkok A, Canter H, Schaal S.

Ophthalmic Surg Lasers Imaging Retina. 2016 Jan 1;47(1):35-41. doi: 10.3928/23258160-20151214-05.



High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy

Madonna R, Giovannelli G, Confalone P, Renna FV, Geng YJ, De Caterina R.

Cardiovasc Diabetol. 2016 Jan 29;15(1):18. doi: 10.1186/s12933-016-0342-4. (full text link)



Evaluation of Preretinal Neovascularization in Proliferative Diabetic Retinopathy Using Optical Coherence Tomography Angiography

de Carlo TE, Bonini Filho MA, Baumal CR, Reichel E, Rogers A, Witkin AJ, Duker JS, Waheed NK.

Ophthalmic Surg Lasers Imaging Retina. 2016 Feb 1;47(2):115-9. doi: 10.3928/23258160-20160126-03.



Changes observed in diabetic retinopathy: eight-year follow-up of a Spanish population

Romero-Aroca P, de la Riva-Fernandez S, Valls-Mateu A, Sagarra-Alamo R, Moreno-Ribas A, Soler N.

Br J Ophthalmol. 2016 Jan 14. pii: bjophthalmol-2015-307689. doi: 10.1136/bjophthalmol-2015-307689. [Epub ahead of print] (full text link)


Dry Eye

Drug and Therapeutics Bulletin review: The management of dry eye

Drugs and Therapeutic Bulletin           This review covers the management of this common condition focusing on the use of artificial tears and ocular lubricants

Clinical Characteristics of Dry Eye Patients With Chronic Pain Syndromes Jelle Vehof, Nicole Sillevis Smitt-Kamminga, Diana Kozareva, Simone A. Nibourg, Christopher J. Hammond

AJJO  Volume 162, February 2016, Pages 59–65.e2 (link to pdf)

Ciclosporin for treating dry eye disease that has not improved despite treatment with artificial tears

Technology appraisal guidance Published: 16 December 2015 nice.org.uk/guidance/ta369


Prevalence of dry eye disease in visual display terminal workers: a systematic review and meta-analysis.

Courtin RPereira BNaughton GChamoux AChiambaretta FLanhers CDutheil F

BMJ Open. 2016 Jan 14;6(1) (full text link)

TearLab osmolarity system for diagnosing dry eye disease - medtech innovation briefing (MIB47)


...done in an ophthalmology outpatient setting...people to an optometrist or an ophthalmologist. Anoptometrist test costs...tariff for an ophthalmology outpatient...consultant ophthalmologists. The manufacturer...community optometrists, working...ophthalmology or optometry practices for...ophthalmologists or ophthalmic nurse practitioners...

National Institute for Health and Care Excellence - NICE - 15 December 2015



Combination Therapy of Intense Pulsed Light Therapy and Meibomian Gland Expression (IPL/MGX) Can Improve Dry Eye Symptoms and Meibomian Gland Function in Patients With Refractory Dry Eye: A Retrospective Analysis.

Vegunta S, Patel D, Shen JF.

Cornea. 2016 Mar;35(3):318-22.


SkQ1 Ophthalmic Solution for Dry Eye Treatment: Results of a Phase 2 Safety and Efficacy Clinical Study in the Environment and During Challenge in the Controlled Adverse Environment Model.

Petrov A, Perekhvatova N, Skulachev M, Stein L, Ousler G.

Adv Ther. 2016 Jan;33(1):96-115. doi: 10.1007/s12325-015-0274-5. Epub 2016 Jan 5. (full text link)


In pursuit of objective dry eye screening clinical techniques

Kanellopoulos AJ, Asimellis G.

Eye Vis (Lond). 2016 Jan 18;3:1. doi: 10.1186/s40662-015-0032-4. eCollection 2016. Review. (full text link)


Efficacy and Safety of Carbomer-Based Lipid-Containing Artificial Tear Formulations in Patients With Dry Eye Syndrome.

Chung SH, Lim SA, Tchach H.

Cornea. 2016 Feb;35(2):181-6.

The Matrix Metalloproteinase 9 Point-of-Care Test in Dry Eye

Lanza NL, Valenzuela F, Perez VL, Galor A.

Ocul Surf. 2016 Feb 2. pii: S1542-0124(16)00008-2. doi: 10.1016/j.jtos.2015.10.004. [Epub ahead of print] Review.


Randomized Multicenter, Double-Blind Study of the Safety and Efficacy of 1%D-3-Hydroxybutyrate eye drops for Dry Eye Disease


Kawakita T, Uchino M, Fukagawa K, Yoshino K, Shimazaki S, Toda I, Tanaka M, Arai H, Sakatani K, Hata S, Okano T, Tsubota K.

Sci Rep. 2016 Feb 11;6:20855. (full text link)


Effect of Moisture Chamber Spectacles on Tear Functions in Dry Eye Disease


Shen G, Qi Q, Ma X.

Optom Vis Sci. 2016 Feb;93(2):158-64.


Efficacy and Safety of 0.2% Hyaluronic Acid in the Management of Dry Eye Disease

Pinto-Fraga J, López-de la Rosa A, Blázquez Arauzo F, Urbano Rodríguez R, González-García MJ.

Eye Contact Lens. 2016 Jan 16. [Epub ahead of print]


Topical Fluorometholone Protects the Ocular Surface of Dry Eye Patients from Desiccating Stress: A Randomized Controlled Clinical Trial

Pinto-Fraga J, López-Miguel A, González-García MJ, Fernández I, López-de-la-Rosa A, Enríquez-de-Salamanca A, Stern ME, Calonge M.

Ophthalmology. 2016 Jan;123(1):141-53. doi: 10.1016/j.ophtha.2015.09.029. Epub 2015 Oct 29.

 (full text link)


Comparison of the Abilities of SD-OCT and SS-OCT in Evaluating the Thickness of the Macular Inner Retinal Layer for Glaucoma Diagnosis.

Lee KM, Lee EJ, Kim TW, Kim H.

PLoS One. 2016 Jan 26;11(1):e0147964. doi: 10.1371/journal.pone.0147964. eCollection 2016.

PMID: 26812064 [PubMed - in process] (full text link)

Evaluation of Frequency-Doubling Technology Perimetry as a Means of Screening for Glaucoma and Other Eye Diseases Using the National Health and Nutrition Examination Survey

Michael V. Boland, MD, PhD1,2,3; Priya Gupta, MD1; Fang Ko, MD4; Di Zhao, PhD5,6; Eliseo Guallar, MD, DrPH5,6; David S. Friedman, MD, PhD1,4

JAMA Ophthalmol. 2016;134(1):57-62. doi:10.1001/jamaophthalmol.2015.4459. (full text available to read in eye library)

Association Between Trabecular Meshwork Anteroposterior Length and Anterior Chamber Angle Width

Roland Y. Lee, Shuai-Chun Lin, Rebecca I. Chen, Diego T. Barbosa, Shan C. Lin

AJJO Volume 162, February 2016, Pages 53–58.e1 (link to pdf)


Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes  Silverman, Anna L. et al.

Ophthalmology , Volume 123 , Issue 2 , 408 – 414 (full text link)

Paediatric Ophthalmology

Amblyopia in children (aged 7 years or less) BMJ Clinical Evidence

Conservative treatment of retinoblastoma: a prospective phase II randomized trial of neoadjuvant chemotherapy followed by local treatments and chemothermotherapy 

L Lumbroso-Le Rouic, I Aerts, D Hajage, C Lévy-Gabriel, A Savignoni, N Algret, N Cassoux, A-I Bertozzi, M Esteve, F Doz and L Desjardins

Eye 30: 46-52; advance online publication, October 2, 2015; doi:10.1038/eye.2015.179 (link to full text)


Evaluation the adjunctive use of combined bevacizumab and mitomycinc to trabeculectomy in management of recurrent pediatric glaucoma 

R A Mahdy, S M Al-Mosallamy, M A Al-Aswad, A Bor'i and W M El-Haig

Eye 30: 53-58; advance online publication, October 2, 2015; doi:10.1038/eye.2015.182 (link to full text)


Nasolacrimal duct intubation in the treatment of congenital nasolacrimal duct obstruction in older children 

S Okumuş, V Öner, C Durucu, E Coşkun, Ü Aksoy, E Durucu, L Şahin and I Erbağcı

Eye 30: 85-88; advance online publication, October 9, 2015; doi:10.1038/eye.2015.189 (link to full text)



Palejwala, Neal V.; Gale, Michael J.; Clark, Rebecca F.; More

Retina. 36(1):119-130, January 2016.



Gupta, Shikha; Gogia, Varun; Jose, Cijin; More

Retina. 36(1):188-191, January 2016.


Radial Retinal Incisions for Complex Pediatric Traumatic Macular Holes

Shah, Aparna A.; Thomas, Benjamin J.; Yonekawa, Yoshihiro; More

Retina. 36(1):211-215, January 2016.


Results of Deep Anterior Lamellar Keratoplasty for Advanced Keratoconus in Children Less Than 18 Years  Ritu Arora, Pooja Jain, Parul Jain, Aditi Manudhane, JawaharLal Goyal

AJJO Feb 2016, 162 191-198.e2  (pdf link)

Rates of Reoperation and Abnormal Binocularity Following Strabismus Surgery in Children Christopher T. Leffler, Kamyar Vaziri, Stephen G. Schwartz, Kara M. Cavuoto, Craig A. McKeown, Krishna S. Kishor, Adam C. Janot

AJJO 2016;162:159–166 (pdf link)

Retinal Oximetry with Scanning Laser Ophthalmoscope in Infants (this is abstract & full text link)    

Wouter B. Vehmeijer, Vigdis Magnusdottir, Thorunn S. Eliasdottir, Sveinn Hakon Hardarson, Nicoline

E. Schalij-Delfos, Einar Stefánsson

PLoS ONE; 2/3/2016, Vol. 11 Issue 2, p1-11, 11p

Neurodevelopmental Outcomes in Infants with Retinopathy of Prematurity and Bevacizumab Treatment (this is abstract & full text link)

Reyin Lien, Mu-Hsien Yu, Kuang-Hung Hsu, Pei-Ju Liao, Yen-Po Chen, Chi-Chun Lai, Wei-Chi Wu

PLoS ONE; 1/27/2016, Vol. 11 Issue 1, p1-12, 12p

Evaluation of Screening for Retinopathy of Prematurity by ROPtool or a Lay Reader Abbey, Ashkan M. et al.

Ophthalmology , Volume 123 , Issue 2 , 385 - 390 (full text link)

Severe eye damage in infants with microcephaly is presumed to be due to Zika virus

BMJ 2016; 352  (Published 10 February 2016)

Rates of Reoperation and Abnormal Binocularity Following Strabismus Surgery in Children

Christopher T. Leffler et al Feb 2016,162,pgs 159-66e9 (full text link)Web publication date: 05 January 2016 (based on January 2014 search) Web publication date: 05 January 2016



Marsiglia, Marcela; Gallego-Pinazo, Roberto; Cunha de Souza, Eduardo; More

Retina. 36(1):64-74, January 2016.



Karapetyan, Anushavan; Ouyang, Pingbo; Tang, Luo Sheng; More

Retina. 36(1):82-90, January 2016



Stanga, Paulo E.; Jaberansari, Horj; Bindra, Mandeep S.; More

Retina. 36(1):156-162, January 2016.


Bimanual Technique for Retinal Tacking of Epiretinal Prosthesis

Gregori, Ninel Z.; Davis, Janet L.; Rizzo, Stanislao

Retina. 36(1):199-202, January 2016.

Inverted Internal Limiting Membrane Insertion for Macular Hole–Associated Retinal Detachment in High Myopia San-Ni Chen, Chung-May Yang

AJJO Volume 162, February 2016, Pages 99–106.e1 (pdf link)


Five-Year Clinical Trial on Atropine for the Treatment of Myopia 2 Chia, Audrey et al.

Ophthalmology , Volume 123 , Issue 2 , 391 – 399 (full text link)

Clinical Validation of a Smartphone-Based Adapter for Optic Disc Imaging in Kenya

Andrew Bastawrous, MBChB, BSc(Hons), FHEA, MRCOphth  Mario Ettore Giardini, PhD et al

JAMA Ophthalmol2016;134(2):151-158 (available to read in eye library)

Macular Bruch Membrane Holes in Choroidal Neovascularization–Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

Kyoko Ohno-Matsui et al

American Journal Ophthalmology 2016,162,133-39e1 (full text link)


Uveitis and Systemic Inflammatory Markers in Convalescent Phase of Ebola Virus Disease.

Chancellor JR, Padmanabhan SP, Greenough TC, Sacra R, Ellison RT 3rd, Madoff LC, Droms RJ, Hinkle DM, Asdourian GK, Finberg RW, Stroher U, Uyeki TM, Cerón OM.

Emerg Infect Dis. 2016 Feb;22(2):295-7. doi: 10.3201/eid2202.151416.

PMID:26812218  (full text link)



Oral Fluoroquinolones and the Risk of Uveitis

Harpal Singh Sandhu, MD1; Alexander J. Brucker, MD1; Liyuan Ma, MSc2; Brian L. VanderBeek, MD, MPH1,2,3

JAMA Ophthalmol. 2016;134(1):38-43. doi:10.1001/jamaophthalmol.2015.4092. (full text available to read in eye library)

 "Remission of Intermediate Uveitis: Incidence and Predictive Factors." Kempen, J. H., et al.

 Am J Ophthalmol. Available online 6 January 2016 (full text link)


Enhanced Depth Imaging Optical Coherence Tomography in Uveitis: An Intravisit and Interobserver Reproducibility Study 

Kim, J. S., et al.  Am J Ophthalmol 164: 49-56. (full text link)


Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study

Janet T. Holbrook  Elizabeth A. Sugar Am J Ophthalmol 164: 29-36. (full text link)



Aflibercept as primary treatment for myopic choroidal neovascularisation: a retrospective study 

C Bruè, A Pazzaglia, C Mariotti, M Reibaldi and A Giovannini

Eye 30: 139-145; advance online publication, October 30, 2015 (link to full text)



Tabatabaei, Seyed Ali; Soleimani, Mohammad; Behrooz, Mahmood Jabbarvand; More

Retina. 36(2):360-365, February 2016.


Efficacy of Intracameral Moxifloxacin Endophthalmitis Prophylaxis at Aravind Eye Hospital  Haripriya, Aravind et al.

Ophthalmology , Volume 123 , Issue 2 , 302 – 308 (full text link)

Risk of Hemorrhage during Needle-Based Ophthalmic Regional Anesthesia in Patients Taking Antithrombotics: A Systematic Review.

Takaschima AMarchioro PSakae TMPorporatti ALMezzomo LADe Luca Canto G

PLoS One. 2016 Jan 22;11(1) (full text link)

News from NICE

Insertion of a subretinal prosthesis system for retinitis pigmentosa


Interventional procedure guidance Published: 16 December 2015


AdenoPlus point-of-care test for diagnosing adenoviral conjunctivitis

Medtech innovation briefing

Published: 15 December 2015


Regular monthly and “as needed” injections for wet age-related macular degeneration are similar in effect

National Institute for Health Research Signal

Eyes and vision A synopsis and expert commentary is provided of this meta-analysis which did not find a meaningful difference in outcomes between monthly and as-needed injections of vascular endothelial growth factor inhibitors for wet age-related macular degeneration.

AdenoPlus point-of-care test for diagnosing adenoviral conjunctivitis - medtech innovation briefing (MIB46)


...practitioners and ophthalmologists in using the...Journal of Ophthalmology 121: 711...2012) General Ophthalmic Services, Activity...Association Ophthalmology 131: 17...Management ofophthalmic disease in general...College of Optometrists (2014) Conjunctivitis...InvestigativeOphthalmology & Visual Science...

National Institute for Health and Care Excellence - NICE - 15 December 2015


NHS Networks

19:03pm, 29 January 2016
Quality standard for people with sight loss and dementia
The Royal College of Ophthalmologists and the Vision 2020 UK dementia and sight loss committee have developed a quality standard to help eye clinics and ophthalmology departments provide high quality care for patients with dementia.

16:15pm, 12 February 2016
Health minister backs bigger role for optical practices
Health minister Alistair Burt told delegates at 100% Optical that patients shouldn’t see GPs for every medical ailment, and that CCGs need to use the whole range of health professionals – including those in eye care to innovate in health delivery.

NEI News

Researchers discover three glaucoma related genes

An analysis funded by the National Eye Institute (NEI), part of the National Institutes of Health, has identified three genes that contribute to the most common type of glaucoma. The study increases the total number of such genes to 15.

Posted on Jan 11, 2016


Retinal cells work with little reserve energy; may explain vunerability to eye diseases


Our eyes are especially demanding when it comes to energy: Along with our brain, they require a substantial amount of power to keep them functioning and healthy.

Posted on Jan 8, 2016


Drug “cocktail”could restore vision in optic nerve injury

January 14 2016

In the News

5 February 2016

Could statins treat common cause of vision loss?

NHS Choices has reported details of a small scale trial following media coverage. In this trial 10 of 23 adults with dry age-related macular degeneration experienced some vision improvement whilst taking atorvastatin 80mg.

Links to the Science

Miller JW, Vavvas DG, Daniels AB, et al. 

Regression of some high-risk features of age-related macular degeneration (AMD) in patients receiving intensive statin treatment   EBioMedicine. Published online February 4 2016 


A case of non-lacrimal immunoglobulin G4 (IgG4)-related orbital disease with mastitis.

Farooq TA1,2Mudhar H3Sandramouli S4.

Orbit. 2015 Dec 23:1-4. [Epub ahead of print] (full text link)



Osseointegrated implants for orbito-facial prostheses: Preoperative planning tips and intraoperative pearls


Leslie A. WeiJulie J. BrownDori K. Hosek & Cat N. Burkat

Orbit Published on-line 28 January 2016               (full text link)


Efficacy of tightening of orbicularis oculi muscle in patients with functional nasolacrimal duct obstruction

Hossein Salour  Keivan Khosravifard  Abbas Bagheri  Yalda Abrishami  Bahareh Kheiri  & Mehdi Tavakoli

Orbit Volume 35Issue 1, 2016 11-15 (full text link)



Digital import of orbital implants to enhance navigation in reconstruction of the deep orbit

Iain VarleyLindsay WhiteSachin M. Salvi  & Nicholas Lee

Orbit Volume 35Issue 1, 2016 20-23 (full text link)


Shared buccal mucosal graft for simultaneous repair of severe upper and lower eyelid cicatricial entropion

Trevor Kerr & Ronald Mancini

Orbit Volume 35Issue 1, 2016 22-28 (full text link)

A single- versus double-layered closure technique for full-thickness lower eyelid defects: a comparative study

Jennifer S. N. Verhoekx,  Renoe K et al


Acta Ophthalmol. 2015 Dec 15. doi: 10.1111/aos.12927. [Epub ahead of print]








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