OUTREACH LIBRARIAN SERVICE
June 2011 - Issue 1
EVIDENCE UPDATE:
Infections or Sepsis in elderly patients
This fact sheet provides an overview of recent evidence relevant to Infections and sepsis in elderly patients; Health surveillance models currently used and Delays in treatment - antibiotics and information on how the “Outreach Librarian Service” can support you to keep up-to-date .
Selected Evidence
Electronic Books (available through your Athens account—MD Consult)
Diagnosis of systemic inflammatory response syndrome
Walsh: Palliative Medicine, 1st ed. Chapter 90—Emergencies in Palliative Medicine—Sepsis .
..Liver function tests Helpful in localizing sepsis; consider biliary sepsis, especially in elderly patients with
no obvious localizing signs...cultures Part of the diagnostic workup for sepsis Lumbar puncture and
cerebrospinal fluid examination...
Epidemiology
Bope: Conn's Current Therapy 2011, 1st ed.; Section 2 - The Infectious Diseases >> Severe Sepsis and
sceptic shock
remarkable aspect of sepsis, severe sepsis, and septic shock is the relatively...of gram-negative and
candidal sepsis in patients with hematologic malignancies. Although sepsis is most typically a disease of
the elderly, the immune suppressed, and those...
Significance of Screening Bacteriuria
Wein: Campbell-Walsh Urology, 9th ed.; Chapter 8 - Infections of the Urinary Tract >> Bacteriuria in the
Elderly
...Bacteriuria that leads to UTIs in elderly subjects in the presence of underlying...lead to severe renal
damage. Sepsis and its sequel (sepsis syndrome and septic shock) are increasingly common in the
elderly. This is in part due to the aggressive...
Reports
Delirium: Diagnosis, prevention and management
NICE clinical guideline 103 July 2010
http://www.nice.org.uk/nicemedia/live/13060/49909/49909.pdf
Guidelines on Urological Infections (Sepsis)
M. Grabe (Chairman), T.E. Bjerklund-Johansen, H. Botto, M. Çek, K.G. Naber, P. Tenke, F. Wagenlehner
European Association of Urology 2010
http://www.uroweb.org/gls/pdf/Urological%20Infections%202010.pdf
Management of patients with Dementia - A National Clinical Guideline
Scottish Intercollegiate Guidelines Network - Sign (86) 2011
http://www.sign.ac.uk/pdf/sign86.pdf
Articles
Abad, CL; Kumar, A and Safdar, N
Antimicrbial therapy of sepsi and septic shock—When are two drugs better than one? (Review article)
Critical Care Clinics April 2011: 27(2) e1-e27
Ahmed NN, Pearce SE (2010)
Acute care for the elderly: a literature review.
Population Health Management 2010 Aug; 13(4):219-25.
Alejandra, MM; Lansang, MAD; Dans, LF and Mantaring III JB
Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock
(Intervention Review)
The Cochrane Library Review 2010: Issue 2
http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD001090/pdf...
Angus, DC
The lingering consequences of sepsis: A hidden public health disaster?
Journal of the American Medical Association (JAMA) June 2011: 305(21) 2145-2244
Casserly, B; Read, R and Levy MM
Hemodynamic monitoring in sepsis
Critical Care Nursing Clinics of North America March 2011: 23(1) 149-169
Caterino, JM; Jalbuena, T and Bogucki, B
Predictors of acute decomposition after admission in ED patients with sepsis
American Journal of Emergency Medicine June 2010: 28(5) 631-636
Coen, D; Vaccaro, A; Cazzaniga, M; Cortellaro, F; Monti, G and Tombini, V
Toward a noninvasive approach to early goal-directed therapy
Chest March 2011: 139(3) 726-7
Crowe, CA; Mistry, CD; Rzechula, K and Kulstad, CE
Evaluation of a modified early goal-directed therapy protocol
American Journal of Emergency Medicine July 2010: 28(6) 689-693
Daniels, R; Nutbeam, T; McNamara, G and Galvin, C
The sepsis six and the severe sepsis resuscitation bundle: A prospective observational cohort study
Emergency Medicine Journal June 2011: 28: 507-512
Francis, M; Rich, T; Williamson, T and Peterson, D
Effect of an emergency department sepsis protocol on time to antibiotics in severe sepsis
Canadian Journal of Emergency Medical Care (CEJM) July 2010: 12(4) 303-310
Gaieski, DF; Mikkelsen, ME; Band, RA; Pines, JM; Massone, R and Furia, FF
Impact of time to antibiotics on survival of patients with severe sepsis or septic shock in whom
goal-directed therapy was initiated in the emergency department
Critical Care Medicine April 2010: 38(4) 1045-1053
Gomes Silva, BN; Andriolo, RB; Atallah, AN and Salomao, R
De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock
(Intervention Review)
The Cochrane Library Review 2010: Issue 2
http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD007934/pdf...
Goyal, M; Pines, JM; Byron, C; Drumheller, DF and Gaeski, DF
Point-of-care testing at triage decreases time to lactate level in septic patients
Journal of Emergency Medicine June 2010: 38(5) 578-581
Kouroumichakis, I; Papanas, N; Proikaki, S; Zarogoulidis, P and Maltezos, E
Statins in prevention and treatment of severe sepsis and septic shock
European Journal of Internal Medicine April 2011: 22(2) 125-133
Kumar, A; Safdar, N; Kethireddy, S and Chateau, D
A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and
septic shock is contingent only on risk of death: A meta-analytic/meta-regression study
Critical Care Medicine 2010: 38(8) 1651-1664
Marti-Carvajal, AJ; Sola, I; Lathyris, D and Cardona, AF
Human recombinant activated protein C for severe sepsis
Intervention Review)
The Cochrane Library Review 2010: Issue 4
http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD004388/pdf...
Meurer, WJ; Losman, ED; Smith, BL; Malani, PN and Younger, JG
Short-term functional decline of older adults admitted for suspected sepsis
The American Journal of Emergency Medicine 2010: (E Pub ahead of print)
Mikkelsen, ME; Gaieski, DF; Goyal, M; Miltiades, AN; Munson, JC; Pines, JM and Fuchs, BD
Factors associated with nonadherence to early goal-directed therapy in the ED
Chest September 2010: 138(3) 551-558
Nee, PA and Rivers, EP
The end of the line for the surviving sepsis campaign, but not for early goal-directed therapy
Emergency Medicine Journal January 2011: 28(3-4) 1472-0213
Nelson, JL; Smith, BL; Jared, JD and Younger, JG
Prospective trial of real-time electronic surveillance to expedite early care of severe sepsis
Annals of Emergency Medicine May 2011: 57(5) 500-504
Powell, ES; Khare, RK; Courtney, DM and Feinglass, J
Volume of emergency department admissions for sepsis is related to inpatient mortality: Results of a
nationwide cross-sectional analysis
Critical Care Medicine November 2010: 38(11) 2161-2168
Schorr, C
Performance improvement in the management of sepsis (Review article)
Critical Care Nursing Clinics of North America March 2011: 23(1) 203-213
Shorr, AF; Micek, ST; Welch, EC; Doherty, JA; Reichley, RM, Kollef, MH
Inappropriate antibiotic therapy in Gram-negative sepsis increases hospital length of stay
Critical Care Medicine January 2011: 39(1) 46-51
Seymour, CW; Cooke, CR; Mikklesen, ME; Hylton, J; Rea, TD; Goss, CH; Gaeski, DF and Band, RA
Out-of-hospital fluid in severe sepsis: Effect on early resuscitation in the emergency department
Prehospital Emergency Care April 2010: 14(2) 145-152
Siddiqui, S and Razzack, J
Early versus late pre-intensive care unit admission broad spectrum antibiotics for severe sepsis in
adults (Intervention Review)
The Cochrane Library Review 2010: Issue 10
http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD007081/pdf...
Sweet, DD; Jaswal, D; Bouchard, M; Sivapalan, P; Rachel, J and Chittock, D
Effect of an emergency department sepsis protocol on the care of septic patients admitted to the
Intensive care unit
Canadian Journal of Emergency Medical Care (CJEM) September 2010: 12(5) 414-420
Tiruvoipati, R; Ong, K; Gangopadhyay, H; Arora, S and Botha, J
Hypothermia predicts mortality in critically ill elderly patients with sepsis
BMC Geriatrics 2010: 10(70) 1471-2318
Wang, HE; Weaver, MD; Shapiro, NI and Yealy, DM
Opportunities for emergency medical services care of sepsis
Resuscitation February 2010: 81(2) 193-197
Yang, Y; Yang, KS; Hsann, YM; Lim, V and Ong, BC
The effect of comorbidity and age on hospital mortality and length of stay in patients with sepsis
Journal of Critical Care September 2010: 25(3) 398-405
Zubert, S; Funk, DJ and Kumar, A
Antibiotics in sepsis and septic shock: Like everything else in life, timing is everything
Critical Care Medicine April 2010:38(4) 1211-1212
How can I help you?
Literature search service
I can offer an expert, in-depth literature search service to help you locate the evidence on any health
related topic.
Training
If you want to learn to navigate the wealth of available online healthcare information and how to search
databases more effectively, the ‘Trust trainer’ can offer timetabled hands-on training sessions or can
provide customised one-to-one support. Telephone: 0121 424 0583 or email:
Current awareness services
If you need to keep up-to-date on a particular topic I can advise on suitable RSS feeds and help you set
up article alerts from the major healthcare databases.
Online resources
Whilst many good quality resources are freely available, most full-text journals and the main biblio-
graphic databases (e.g. Medline and CINAHL) require an Athens username and password. To register
for an Athens login go to www.athens.nhs.uk
The Library web pages contain detailed information about library services and training opportunities,
online request and registration forms and several guides on key online resources and evidence-based
websites at www.heftlibrary.nhs.uk
Contact
The Outreach Librarian is located in the education centre at Heartlands Hospital, on the first floor, next
to the Library.
Telephone 0121 424 2583 (42583) or email: [email protected]