Infection and Sepsis- June 2011

OUTREACH LIBRARIAN SERVICE

June 2011 - Issue 1

EVIDENCE UPDATE:

Infections or Sepsis in elderly patients

This fact sheet provides an overview of recent evidence relevant to Infections and sepsis in elderly patients;  Health  surveillance   models   currently  used  and  Delays   in  treatment   -  antibiotics  and information on how the “Outreach Librarian Service” can support you to keep up-to-date .

Selected Evidence

Electronic Books (available through your Athens account—MD Consult)

Diagnosis of systemic inflammatory response syndrome

Walsh: Palliative Medicine, 1st ed. Chapter 90—Emergencies in Palliative Medicine—Sepsis .

..Liver function tests Helpful in localizing sepsis; consider biliary sepsis, especially in elderly patients with

no obvious localizing signs...cultures Part of the diagnostic workup for sepsis Lumbar puncture and

cerebrospinal fluid examination...

Epidemiology

Bope: Conn's Current Therapy 2011, 1st ed.; Section 2 - The Infectious Diseases >> Severe Sepsis and

sceptic shock

remarkable aspect of sepsis, severe sepsis, and septic shock is the relatively...of gram-negative and

candidal sepsis in patients with hematologic malignancies. Although sepsis is most typically a disease of

the elderly, the immune suppressed, and those...

Significance of Screening Bacteriuria

Wein: Campbell-Walsh Urology, 9th ed.; Chapter 8 - Infections of the Urinary Tract >> Bacteriuria in the

Elderly

...Bacteriuria that leads to UTIs in elderly subjects in the presence of underlying...lead to severe renal

damage. Sepsis and its sequel (sepsis syndrome and septic shock) are increasingly common in the

elderly. This is in part due to the aggressive...

Reports

Delirium: Diagnosis, prevention and management

NICE clinical guideline 103 July 2010

http://www.nice.org.uk/nicemedia/live/13060/49909/49909.pdf

Guidelines on Urological Infections (Sepsis)

M. Grabe (Chairman), T.E. Bjerklund-Johansen, H. Botto, M. Çek, K.G. Naber, P. Tenke, F. Wagenlehner

European Association of Urology    2010

http://www.uroweb.org/gls/pdf/Urological%20Infections%202010.pdf

Management of patients with Dementia -     A National Clinical Guideline

Scottish Intercollegiate Guidelines Network -      Sign (86) 2011

http://www.sign.ac.uk/pdf/sign86.pdf

Articles

Abad, CL; Kumar, A and Safdar, N

Antimicrbial therapy of sepsi and septic shock—When are two drugs better than one? (Review article)

Critical Care Clinics April 2011: 27(2) e1-e27

Ahmed NN, Pearce SE (2010)

Acute care for the elderly: a literature review.

Population Health Management 2010 Aug; 13(4):219-25.

Alejandra, MM; Lansang, MAD; Dans, LF and Mantaring III JB

Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock

(Intervention Review)

The Cochrane Library Review 2010: Issue 2

http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD001090/pdf...

Angus, DC

The lingering consequences of sepsis: A hidden public health disaster?

Journal of the American Medical Association (JAMA) June 2011: 305(21) 2145-2244

Casserly, B; Read, R and Levy MM

Hemodynamic monitoring in sepsis

Critical Care Nursing Clinics of North America March 2011: 23(1) 149-169

Caterino, JM; Jalbuena, T and Bogucki, B

Predictors of acute decomposition after admission in ED patients with sepsis

American Journal of Emergency Medicine June 2010: 28(5) 631-636

Coen, D; Vaccaro, A; Cazzaniga, M; Cortellaro, F; Monti, G and Tombini, V

Toward a noninvasive approach to early goal-directed therapy

Chest March 2011: 139(3) 726-7

Crowe, CA; Mistry, CD; Rzechula, K and Kulstad, CE

Evaluation of a modified early goal-directed therapy protocol

American Journal of Emergency Medicine July 2010: 28(6) 689-693

Daniels, R; Nutbeam, T; McNamara, G and Galvin, C

The sepsis six and the severe sepsis resuscitation bundle: A prospective observational cohort study

Emergency Medicine Journal June 2011: 28: 507-512

Francis, M; Rich, T; Williamson, T and Peterson, D

Effect of an emergency department sepsis protocol on time to antibiotics in severe sepsis

Canadian Journal of Emergency Medical Care (CEJM) July 2010: 12(4) 303-310

Gaieski, DF; Mikkelsen, ME; Band, RA; Pines, JM; Massone, R and Furia, FF

Impact of time to antibiotics on survival of patients with severe sepsis or septic shock in whom

goal-directed therapy was initiated in the emergency department

Critical Care Medicine April 2010: 38(4) 1045-1053

Gomes Silva, BN; Andriolo, RB; Atallah, AN and Salomao, R

De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock

(Intervention Review)

The Cochrane Library Review 2010: Issue 2

http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD007934/pdf...

Goyal, M; Pines, JM; Byron, C; Drumheller, DF and Gaeski, DF

Point-of-care testing at triage decreases time to lactate level in septic patients

Journal of Emergency Medicine June 2010: 38(5) 578-581

Kouroumichakis, I; Papanas, N; Proikaki, S; Zarogoulidis, P and Maltezos, E

Statins in prevention and treatment of severe sepsis and septic shock

European Journal of Internal Medicine April 2011: 22(2) 125-133

Kumar, A; Safdar, N; Kethireddy, S and Chateau, D

A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and

septic shock is contingent only on risk of death: A meta-analytic/meta-regression study

Critical Care Medicine 2010: 38(8) 1651-1664

Marti-Carvajal, AJ; Sola, I; Lathyris, D and Cardona, AF

Human recombinant activated protein C for severe sepsis

Intervention Review)

The Cochrane Library Review 2010: Issue 4

http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD004388/pdf...

Meurer, WJ; Losman, ED; Smith, BL; Malani, PN and Younger, JG

Short-term functional decline of older adults admitted for suspected sepsis

The American Journal of Emergency Medicine 2010: (E Pub ahead of print)

Mikkelsen, ME; Gaieski, DF; Goyal, M; Miltiades, AN; Munson, JC; Pines, JM and Fuchs, BD

Factors associated with nonadherence to early goal-directed therapy in the ED

Chest September 2010: 138(3) 551-558

Nee, PA and Rivers, EP

The end of the line for the surviving sepsis campaign, but not for early goal-directed therapy

Emergency Medicine Journal January 2011: 28(3-4) 1472-0213

Nelson, JL; Smith, BL; Jared, JD and Younger, JG

Prospective trial of real-time electronic surveillance to expedite early care of severe sepsis

Annals of Emergency Medicine May 2011: 57(5) 500-504

Powell, ES; Khare, RK; Courtney, DM and Feinglass, J

Volume of emergency department admissions for sepsis is related to inpatient mortality: Results of a

nationwide cross-sectional analysis

Critical Care Medicine November 2010: 38(11) 2161-2168

Schorr, C

Performance improvement in the management of sepsis (Review article)

Critical Care Nursing Clinics of North America March 2011: 23(1) 203-213

Shorr, AF; Micek, ST; Welch, EC; Doherty, JA; Reichley, RM, Kollef, MH

Inappropriate antibiotic therapy in Gram-negative sepsis increases hospital length of stay

Critical Care Medicine January 2011: 39(1) 46-51

Seymour, CW; Cooke, CR; Mikklesen, ME; Hylton, J; Rea, TD; Goss, CH; Gaeski, DF and Band, RA

Out-of-hospital fluid in severe sepsis: Effect on early resuscitation in the emergency department

Prehospital Emergency Care April 2010: 14(2) 145-152

Siddiqui, S and Razzack, J

Early versus late pre-intensive care unit admission broad spectrum antibiotics for severe sepsis in

adults (Intervention Review)

The Cochrane Library Review 2010: Issue 10

http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD007081/pdf...

Sweet, DD; Jaswal, D; Bouchard, M; Sivapalan, P; Rachel, J and Chittock, D

Effect of an emergency department sepsis protocol on the care of septic patients admitted to the

Intensive care unit

Canadian Journal of Emergency Medical Care (CJEM) September 2010: 12(5) 414-420