Better diabetes care- March 2010


”The case for Tight Glycemic Control in Hospitalized Patients”


Listed below is the high level evidence on Tight Glycemic Control produced by NICE, SIGN and NHS based organisations. Also included are the European Society guidelines where available. This list is produced and maintained by HEFT Library Services to support VITAL 4 Medics core skills programme developed in the Trust


HEFT Policies

Control of Hyperglycemia in the ill patient

Phil Dyer, Catherine Holmes, Sharon Jones, Urmila Griffiths HEFT. Next review date September 2012


Map of Medicine



National Guidelines & Non-UK Guidelines (includes Professional Bodies/Associations)

Management of diabetes – A national clinical guideline

SIGN 116 March 2010


Systematic Reviews – Cochrane Library

Eslami S, Abu-Hanna A, de Jonge E

Tight glycemic control and computerized decision-support systems: a systematic review (Structured abstract)
Centre for Reviews and Dissemination 2009


Marik PE, Preiser JC

Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis.

Chest. 2010 Mar;137(3):544-51. Epub 2009 Dec 16.


NHS Evidence


Anabtawi A, Hurst M, Titi M

Incidence of hypoglycemia with tight glycemic control protocols: a comparative study.

Diabetes Technology & Therapeutics 2010 12(8) 635-639


Selig PM, Popek V, Peebles KM.

Minimizing hypoglycemia in the wake of a tight glycemic control protocol in hospitalized patients.

J Nurs Care Qual. 2010 Jul-Sep;25(3):255-60.

Castellanos MR, Rothman J, Kleiner M

Tight glycemic control in critically ill patients

JAMA 2010 303(17) 1694-1695


Turchin  A, Matheny  ME, Shubina  M, Scanlon  JV, Greenwood  B, Pendergrass  ML.  Hypoglycemia and clinical outcomes in patients with diabetes hospitalized in the general ward.

 Diabetes Care.  2009; 32(7):1153–1157.


Wiener  RS, Wiener  DC, Larson  RJ.

 Benefits and risks of tight glucose control in critically ill adults: a meta-analysis

[published correction appears in JAMA. 2009; 301(9):936].  JAMA.  2008;300(8):933–944.


Laha, J, Kopecky, P, Matias, M

Comparison of Three Protocols for Tight Glycemic Control in Cardiac Surgery Patients

Diabetes Care May 2009; 32; 757-761


Perlmuter LC, Flanaghan, BP

Glycemic control and hypoglycaemia: Is the loser the winner?

Diabetes Care 2008; 31(10) 2072-2076


Glycemic control and hypoglycaemia: Is the loser the winner?

Response to Perlmuter et al.

Diabetes Care April 2009 32; e46


Kitabchi  AE, Freire  AX, Umpierrez  GE.  

Evidence for strict inpatient blood glucose control: time to revise glycemic goals in hospitalized patients.  Metabolism.  2008;57(1):116–120.


Nasraway SA Jr

Sitting on the horns of a dilemma: avoiding severe hypoglycemia while practicing tight glycemic control.

Crit Care Med. 2007;35(10):2435.


Varghese P, Gleason V, Sorokin R, Senholzi C, Jabbour S, Gottlieb JE.

Hypoglycemia in hospitalized patients treated with antihyperglycemic agents.

J Hosp Med. 2007 Jul;2(4):234-40.


Braithwaite SS, Buie MM, Thompson CL, Baldwin DF, Oertel MD, Robertson BA, Mehrotra HP.

Hospital hypoglycemia: not only treatment but also prevention.

Endocr Pract. 2004 Mar-Apr;10 Suppl 2:89-99.


Queale  WS, Seidler  AJ, Brancati  FL.

Glycemic control and sliding scale insulin use in medical inpatients with diabetes mellitus.

 Arch Intern Med.  1997; 157(5):545–552.


Bellal Joseph, Jeff Genaw,  Arthur Carlin,  Jack Jordan,  Jean Talley,  Ilan Rubinfeld,

Perioperative Tight Glycemic Control: The Challenge of Bariatric Surgery Patients and the Fear of Hypoglycemic Events

Perm J. 2007 Spring; 11(2): 36–39.


Boucai, L, Southern, WN & Zonszein, J

Hypoglycemia-associated Mortality Is Not Drug-associated but Linked to Comorbidities

American Journal of Medicine November 2011 Volume 124, Issue 11, Pages 1028-1035,